To be selected and consecrated for holy purposes. This appointment is to a specific service within the Church organization by the laying on of hands by someone who has the proper authority. Only those who preside over priesthood quorums receive keys when they are set apart. People set apart to positions other than presidents of priesthood quorums may receive a priesthood blessing, but no keys are given with that blessing.

Separate me Barnabas and Saul for the work, Acts 13: 2-3. Other bishops to be set apart, D&C 68: 14. The bishop, a common judge, shall be set apart unto this ministry, D&C 107: 17, 74. A man must be called of God by prophecy and by the laying on of hands, A of F 1: 5.